Genetic basis of sudden death after COVID-19 vaccination

paramedics pushing man on stretcher

Dr.Peter McCullough published an article January 11, 2023 regarding two studies showing SCN5A variant (which affects the heart) was implicated as the cause of sudden deaths after COVID shots.

These papers raise the concept that not all patients after the injection or those with manifest COVID-19 vaccine-induced myocarditis are at risk for sudden death. In clinical practice doctors should incorporate genetic testing for channelopathies to fine tune the prognosis for patients. COVID-19 vaccine induced myocarditis can be fatal in the setting of a channelopathy such as SCN5A and probably many others.

Meet with your state legislators ASAP to stop and prevent future shot mandates and preserve religious and conscientious exemptions to the shots as the CDC has added the COVID shots to the childhood vaccine schedule, which is the schedule that schools follow.  It is the state that decides if these exemptions will remain or if they will take away these exemptions and only allow for medical exemptions, which is the situation in California since 2016.  The states particularly at risk for removing conscientious and religious exemptions and becoming like California are the new “trifecta” states, which means the Governor’s office, State Senate, and State House became controlled by the same party (that has been pushing mandates) after the November elections.  Those states are Minnesota, Michigan, Maryland, and Massachusetts.

When you meet with your state legislators, show them these two studies which show that some people are genetically predisposed to heart problems after the shots, which has led to sudden deaths.

People with these genetic variants are almost always not aware that they have them. There are likely other genetic variants as well that increase risk of adverse events after the shots, but were never evaluated during the clinical trials because the shots were only tested on healthy individuals.

Two studies:

Inherited Risk of Sudden Death Triggered by COVID-19 Vaccination SCN5A Channelopathy Variants Give Clues for Who May be Next PETER A. MCCULLOUGH, MD, MPH™JAN 11 By Peter A. McCullough, MD.

MPHI mentioned that genetic conditions will be considered in Damar Hamlin’s case. There is an array of known sodium, potassium, and other ion channel mutations in the heart that pose a genetic proclivity to sudden death. In severe mutational cases, the channelopathy is the sole determinant. Many other circumstances, the baseline abnormality and then a superimposed insult to the heart. Two papers (Lim from Korea, Ittiwut from Thailand) now have found that SCN5A variants for cardiomyocyte channels by genetic assessment or by clinical determination on ECG (Brugada pattern) explain cases of sudden death after vaccination.

The Brugada pattern and sudden death is known to be triggered by fever, thus the reactogenic phase of vaccination with fever itself may explain the initiation of VT/VF and cardiac arrest.

I am disappointed that world class electrophysiology research departments at US medical schools are being outclassed by investigators in Asia. COVID-19 vaccine induced myocarditis and sudden death should be a top research priority for every cardiology division in the country at this time. These papers raise the concept that not all patients after the injection or those with manifest COVID-19 vaccine-induced myocarditis are at risk for sudden death. In my clinical practice I incorporate genetic testing for channelopathies to fine tune the prognosis for patients. Let’s hope Damar Hamlin gets high quality of care and critical thinking by electrophysiologists who understand the COVID-19 vaccine induced myocarditis can be fatal in the setting of a channelopathy such as SCN5A and probably many others.

Dr. McCullough on Tucker Carlson Tonight, Jan 3, 2023

So for every 1 million people vaccinated, there would be 20,000-70,000 people with SCN5A variants, and 500 would have Brugada Syndrome.  In the US, there are 330 million people, so there are 6.6 million- 23 milion with SCN5A variants and 165,000 people with Brugada Syndrome.


Add this to the prevalence of PFOs (holes in the heart) in 25% of the population Patent Foramen Ovale (PFO) | American Heart Association [ which Halley Bieber had which increases risk of stroke when blood clots are present]  which means 82.5 million Americans with PFOs, and you end up with millions of people with increased risk of adverse effects after the shots.

This is just considering SCN5A variants and PFOs.  There are many more genetic conditions affecting the heart, and the shots have not been tested for their effects on people with heart conditions. There are likely many more genetic conditions that these shots would aggravate.

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